Animal studies as models for the reaction of the glomerular filtration rate (GFR) to acute changes of protein intake


Wustenberg, P.W.; Chol, H.; Schroder, J.; Nitschke, F.P.; Klinkmann, H.

Zeitschrift für Urologie und Nephrologie 82(3): 93-104

1989


The glomerular filtration rate (GFR) and the tubulo-secretory transport maximum of p-aminohippuric acid (TmPAH) were examined in acute feeding trials (pellets, meat) and after infusion of furosemide, dopamine and glucagon in normal and unilaterally nephrectomized Wistar rats to investigate the start process of GFR increase in an experimental model (apart from the hyperfiltration in residual nephrons) and to confirm paradoxical GFR changes.