Calcium and Phosphorus Metabolism in Osteomalacia. V. The Effect of Varying Levels and Ratios of Calcium to Phosphorus Intake on their Serum Levels, Paths of Excretion and Balances, in the Presence of Continuous Vitamin D Therapy
Liu, S.H.; Su, C.C.; Chou, S.K.; Chu, H.I.; Wang, C.W.; Chang, K.P.
Journal of Clinical Investigation 16(4): 603-611
In two patients, one with osteomalacia. being treated by vitamin D, and the other with syphilitic osteitis of radius and tibia, the serum Ca was fairly constant, but in the osteomalacia case the serum P tended to decrease with increased Ca: P ratio in the diet. A reciprocal relation between urinary Ca and P excretion, and intake was shown in both cases. Faecal Ca and P were also related to intake (see also Abst. 3007, Vol. 5). Retention of both Ca and P was more dependent on the Ca than on the P intake although both were required in fairly large amounts, and with an optimum Ca: P ratio of 2 in order to obtain good healing of the osteomalacia. Continuous administration of vitamin D in this study gave no better healing than the limited dosage in previous cases (see Abst. 2116, Vol. 4).