Clinical experience with cross-protective anti-endotoxin antiserum in dogs with parvoviral enteritis
Canine Practice 16(3): 23-26
Out of 51 puppies testing positive for parvovirus, 30 were divided into three groups of ten each for antiserum treatment. A significant difference (p<0.01) was found between the survival rate of the antiserum treatment group (83%) and control group (52%). Survival rates were 70, 90, and 90%, in the 1, 2, and 4 ml antiserum per lb treatment groups, respectively. Escherichia coli were isolated from 61% of the antiserumtreated puppies, suggesting that gramnegative endotoxins are important contributors to complications of parvoviral infections. No anaphylactic responses were noted.