Major biotransformation routes of some allylamine antimycotics
Battig, F.A.; Nefzger, M.; Schulz, G.
Recent trends in the discovery, development and evaluation of antifungal agents: 479-495
The biological fate of 5 radiolabelled allylamine antimycotics, including naftifine and terbinafine, was investigated in man, rat, dog, guinea pig and rabbit. Absorption, distribution, elimination and biotransformation routes were studied. Major biotransformation routes were N-dealkylation; oxidation at aliphatic and aromatic carbon atoms; conjugation with glucuronic acid and glycine and rupture of the carbon-silicon bond in 1 drug; all were based on the structures of identified metabolites.