Effects of acute protein loads of different sources on glomerular filtration rate
Dhaene, M.; Sabot, J.P.; Philippart, Y.; Doutrelepont, J.M.; Vanherweghem, J.L.
Kidney International. Supplement 22: S25-S28
Three men and 3 women 24 to 31 years old eating a normal diet (protein 1.2 g/kg body weight) underwent pre- and postprandial creatinine clearance estimations after 2 acute protein loads: protein 2 g/kg body weight given in the form of beef or a dietetic preparation, Fortimel, repeated after 1 week. The main differences in protein loads were an absence of carbohydrate in meat, a greater amount of linoleic acid in Fortimel and different proportions of some amino acids. Per g protein meat contains more arginine (x 2), alanine (x 1.8) and glycine (x 2.5) but less proline (x 0.4) than Fortimel. Glomerular filtration rate was higher after red meat intake and postprandial urea excretion was similar after either treatment. After red meat intake there was a strong correlation between the postprandial increases in urea excretion and the increments in creatinine clearances.