Placentrex in the treatment of eczema of canines - clinical report


Babu, S.S.; Sreemannarayana, O.; Lakshmipathi, G.V.

Indian Veterinary Journal 56(2): 147-148

1979


Placentrex injections were tried on clinical cases of non-specific eczematous lesions and were found to yield excellent results.

Whin
vet.
J.
56,
February,
1979:
14/-148
PLACENTREX
IN
THE
TREATMENT
OF
ECZEMA
OF
CANINES-
CLINICAL
REPORT
S.
Surendra
Babu,
0.
Sreemannarayana‚ÄĘ
and
G.
V.
Lakshmipathi**
Clinical
Laboratory.
Veterinary
Hospital,
Nellore,
Andhra
Pradesh
Biological
stimulants
are
introduced
into
the
body
with
the
object
of
stimulating
immunological
or
metabolic
processes
and
are
in
practice
since
a
long
time.
This
is
otherwise
known
as
immunoglobulin
therapy.
The
products
are
of
various
types
namely
proteins
of
animal
or
organismal
origin,
living
organisms,
venoms,
blood
or
whole
tissue
or
their
extracts.
In
the
ancient
system
of
medicine,
placental
tissues
were
extensively
used
as
an
external
dressing
in
cases
of
chronic,
non-healing
wounds
and
ulcers
;
the
hypothesis
being
that
placenta
sustains
and
nourishes
life
and
protects
it
from
external
irritation.
Placental
extract
has
been
used
in
various
conditions
in
medicine,
surgery,
obstetrics,
gynaecology,
ENT,
ophthalmology
and
dermatology
more
specifically
for
eczema,
various
ulcers,
allergic
dermatitis,
burns
and
for
psoriasis
etc.
(Mohan
Mallya,
1971).
Mazzuchi
(1925-cit.
Kral
and
Novak,
1953)
mentioned
that
stimulation
of
the
reticuloendothelial
system
by
administration
of
non-specific
proteins
had
been
employed
with
superior
results
in
acute
and
chronic
eczema.
Schmidt
(1967-cit.
Tice
and
Harvey,
1967)
stated
that
the
daily
intramuscular
injections
of
1
ml
of
placental
extract
was
particularly
helpful
in
eczema
patients
with
hard
scaly
papules.
In
the
present
investigation,
Placentrex
(Albert
David
Ltd,
Calcutta)
a
placental
extract,
was
tried
on
clinical
cases
of
canines
suffering
with
non-specific
eczema
at
the
Veterinary
hospital,
Nellore,
Andhra
Pradesh.
Materials
and
Methods
The
study
was
carried
out
on
61
clinical
cases
of
dogs
i.e
;
38
males
and
25
females.
These
cases
exhibited
eczematous
patches
on
thighs,
tail,
ears,
lumbar
region,
neck,
abdomen
and
in
some
all
over
the
body.
Skin
scrapings
were
found
negative
for
ectoparasites.
Faecal
samples
also
did
not
reveal
any
parasitic
infection.
Placentrex
injections
were
given
intramuscularly
daily
for
5
days
at
the
rate
of
1
ml
per
day.
Of
the
61
cases
treated
at
the
clinic,
44
cases
received
only
placentrex
injections.
Along
with
placentrex
injections,
6
cases
received
salicylic
ointment,
,
4
cases
sulphur
ointment,
1
case
ascabiol,
;
case
livoderm
as
topical
applications
and
5
cases
acetylarsan
injections.
Results
and
Discussion
The
results
are
recorded
in
the
Table.
Out
of
61
cases
treated
with
placentrex
alone
or
in
combination
with
other
medicines,
only
3
cases
did
not
show
any
improvement
(4.9%).
Present
address
:
*Assistent
Director
of
Animal
Husbandry
,Goshalas)
Veterinary
Hospital
Campus,
Seetarampet,
Hyderabad
"Assistant
Professor
of
Surgery,
College
of
Veterinary
Science,
Tirupathi
148
Placentrex
for
eczema
in
canines
Number
of
cases
treated
and
results
No.
of
cases
treated
No.
not
cured
Drugs
used
No.
cured
Placentrex
in
ections
only
Placentrex
injections
+
salicylic
ointment
Placentrex
injections
+
sulphur
ointment
Placentrex
injections
+
acetylarsan
injections
Placentrex
injections
+
ascabiol
application
Placentrex
injections
+
livoderm
application
Total
....
I
61
3
58
44
3
6
4
5
1
1
41
6
4
5
1
1
The
remaining
58
patients
showed
definite
clinical
improvement
and
complete
recovery
in
5
days.
Moreover,
placental
extract
therapy
is
easy
to
administer
and
there
are
no
contra-
indications.
No
un-toward
side
effects
were
noticed
in
the
present
trial.
All
these
evidently
revealed
that
placental
extract
(Placentrex)
can
be
safely
advocated
for
all
the
non-specific
types
of
eczematous
lesions
in
canine
patients.
It
is
postulated
that
placentrex
has
brought
about
the
beneficial
effects
by
stimulation
of
hypophysis
and
suprarenal
cortex,
thus
improving
the
general
metabolism
and
the
defensive
mechanisms.
Because
of
its
steroid
content
and
other
hormones,
it
seems
to
bring
about
the
resolution
of
inflammatory
process
and
correction
of
imbalance
of
hormone
metabolism.
Summary
Placentrex
injections
were
tried
on
clinical
cases
of
non-specific
eczematous
lesions
and
were
found
to
yield
excellent
results.
Acknowledgment
The
authors
wish
to
express
their
thanks
to
Dr.
P.
L.
Narayana
Rao,
Professor
and
Head,
Department
of
Veterinary
Medicine,
College
of
Veterinary
Science,
Tirupathi,
Andhra
Pradesh
for
his
valuable
suggestions.
REFERENCES
Kral,
P.
and
Noavak,
B.J.
(1953)
Mohan
Mallya
(1971)
Tice,
F.
and
Harvey,
J.C.
41967)
Veterinary
Dermatology,
Published
by
J.B.
Lippincot
Co.
Philadelphia,
USA
The
Antiseptic.
68:
655
Common
Diseases
of
Skin.
Practice
of
Medicine,
Published
by
W.F.
Prior
Co.
Inc,
.
Hagger's
Maryland,
USA