Standards for Clostridium chauvoei vaccine the relationship between the response of guinea pigs and sheep following vaccination and challenge with virulent Clostridium chauvoei

Crichton, R.; Harriss, D.A.; Mckay, D.J.

Australian Veterinary Journal 63(3): 68-70


Twelve commercial 5-component clostridial vaccines with known variations in potency of the blackleg (Clostridium chauvoei) component, were simultaneously tested in sheep and guinea pigs. Controlled challenge experiments provided evidence of a highly significant correlation in the response of the 2 species. The guinea pig laboratory model is considered to be a valid indicator of field performance for vaccines containing blackleg antigen.