Some observations on the quality control testing of Clostridium chauvoei vaccines

Chandler, H.M.

Developments in Biological Standardization 32: 137-141


Agglutination tests are not suitable for the estimation of the protective antibody level in the sera of vaccinated animals and should not be used for the quality control testing of blackleg vaccines. Some highly virulent strains of C. chauvoei are only effectively protected against by vaccines containing cells with a heat labile protective antigen in addition to the heat stable antigen common to all cells of C. chauvoei.