Butoconazole vaginal cream in the treatment of vulvovaginal candidiasis. Comparison with miconazole nitrate and placebo
Brown, D.; Henzl, M.R.; LePage, M.E.; Tsao, L.L.; Izu, A.E.; Walker, K.A.; Adamson, G.D.; Droegmuller, W.
Journal of Reproductive Medicine 31(11): 1045-1048
A double-blind, parallel study was conducted comparing a new imidazole derivative, butoconazole nitrate, with placebo and miconazole nitrate for the treatment of vulvovaginal candidiasis. Patients were randomly assigned to six treatment regimens. Butoconazole was found to be an effective antifungal agent in both the six- and three-day treatment schedules. The incidence of local side effects from both tested imidazoles was low.