Observations on the influence of media composition on the efficacy of vaccines derived from some Clostridium chauvoei strains
Bulletin of Animal Health and Production in Africa 33(2): 117-121
Potency tests in guinea pigs with alum-precipitated vaccines prepared with three different C. chauvoei strains grown in liver-liver broth or liver-meat broth (pepsin-hydrochloric acid digest) gave consistently better results with the strains grown in liver-meat broth. Vaccine from the Awasa strain grown in liver-meat broth protected for at least a year. In field trials in cattle and sheep over three years, with vaccine from the Awasa strain grown in liver-meat broth, there were no vaccine breaks or adverse reactions.