Studies in hereditary dwarfism in . mice VIII. The histology of the anterior pituitary of mice with hereditary adiposity and of dwarf mice with hereditary adiposity
Acta Pathologica et Microbiologica Scandinavica 22: 138-143
The anterior pituitary lobe of mice with a hereditary gene for adiposity and yellow coat is of a normal shape and size, and the anterior lobe parenchyma is normal of construction and composition. In the " fat. yellow dwarf mouse " the anterior pituitary lobe is hypoplastic, and the anterior lobe tissue is defective with predominance of small pyknotic acidophiles and chromophobes, just like in the " normal dwarf mouse " with no disposition to adiposity/yellow colour. Unlike the anterior lobe of the " normal dwarf " that of the " fat, yellow dwarf" contains a few hypoacidophiles and small typical acidophiles. The hypothesis is advanced that the gene for adiposity restrains the cycle and action of the pituitary lobe without causing observable morphologic changes in the anterior lobe of the normal mouse, whose cycle is stable.