Insulin sensitivity in the hereditary hypopituitary dwarf mouse
Mirand, E.A.; Osborn, C.M.
Proceedings of the Society for Experimental Biology and Medicine 82(4): 746-748
Since the hereditary hypopituitary dwarf mouse (subline, Syracuse) is deficient in anterior-pituitary and adrenocortical secretions, it was of interest to test insulin effects on this naturally occurring form of hypopituitarism. Under the exptl. conditions employed in these studies, findings may be summarized as follows: (a) the insulin-hypersensitive dwarf mouse can tolerate only 3% of the dose (2 units of insulinAg. of mouse) that produces comparable symptoms in normal mice; higher dosages cause severe hypo-glycemia followed by death; and (b) ACTH, adrenocortical extract, cortisone, and growth hormone act as anti-insulin agents as shown by their ability to increase blood-glucose levels and to reduce hypoglycemic convulsions; desoxycorticosterone acetate and testosterone propionate exhibit no anti-insulin action.