Defect of growth hormone receptors in hereditary hypopituitary dwarf mice


Fouchereau-Peron, M.; Garcia, D.; Rosselin, G.

Annales d'Endocrinologie 37(2): 83-84

1976


The binding of 125I-growth hormone to its specific receptors was comparatively studied in liver cells isolated from dwarf mice and littermates. The specific binding of growth hormone was about eight-fold lower in cells from dwarf mice than in those from littermates. However, the specific binding of insulin, although lower, was not significantly modified in dwarf as compared to littermates. The defect of growth hormone receptors in hypopituitary dwarf mice is likely to be related to the lack of hormonal effect in this animal when the growth hormone was administered alone.