Hepatosplenomegaly of unknown etiology: clinical examination in making a diagnosis in 57 cases

Loredo-Abdalá, A.; Mata-Quezada, L.C.; Carbajal-Rodríguez, L.; Villaseñor-Zepeda, J.

Boletin Medico del Hospital Infantil de Mexico 46(1): 41-46


Fifty-seven patients with the diagnosis of hepatosplenomegaly of unknown cause were studied. Most of the patients were infants and preschool age children. They were evenly distributed by sex. The patients were not undernourished nor did they have low height. However if such was the case, they were usually patients with a metabolic or neoplastic problem. Psychomotor retardation, paleness, jaundice and bleeding were the most common signs and symptoms. Hepatic function tests, complete blood count and urinalysis helped to establish the cause of hepatosplenomegaly in 19 of the 57 patients. Other studies only helped to establish the diagnosis of visceromegaly of unknown cause. Liver biopsy, bone marrow biopsy and a metabolic study were useful to establish the diagnosis in 34 cases. Infectious, metabolic and neoplastic problems were the usual cause for visceromegaly.