Primary pulmonary sarcomas etiology clinical assessment and prognosis with a comparison to pulmonary carcinomas a review of 41 cases and 394 other cases of the literature
Japanese Journal of Surgery 12(2): 148-159
Primary sarcomas of the human lungs occur at frequencies of 1:100, compared with carcinomas reported in retrospective studies covering 394 cases reported in the literature from 1957-1972 and 41 cases from 1957-1974. The average age was 45 yr, the disease usually occurred between the ages of 35-65, the peak being between 45-60 yr. Distribution between sexes was much the same as that seen in general. X-ray with rapid thoracotomy provided the best clinical results. The literature showed a postoperative survival time of 5 yr in 19% and 44% of the reported cases. The general metastasis, hematologenous and lymphogenous were more or less equal and recidive tendency in 7% essentially varied, as related to the single histological forms. Lymphosarcomas (28.6%) were the most frequent, the group of spindle-celled sarcomas, inclusive of leiomyosarcomas, occurred in 40%. Histological maturity of the tissues and the prognosis according to active therapy were in parallel. A comparison of 41 primary sarcomas of the lungs with the 192 cases of carcinomas seen showed no connection between sarcomas of the lungs and smoking of cigarettes, pollution of the environment, industrial toxins or chronic bronchitis. The findings relate to the peripheral localization and to the lack of incidence among men, with regard to pulmonary adenocarcinomas. An overall view of the characteristics led to the assumption of a probable endogenous tumor. A summarization of the characteristics of pulmonary sarcomas and carcinomas revealed the role of primary sarcomas in the total complex of malignant tumors of the lungs.