Experimental treatment of Loa loa with 1-diethyl-carbamyl-4-methylpiperazine

Stefanopoulo, G.J.; Schneider, J.

Comptes Rendus des Séances et Mémoires de la Société de Biologie 142: 930-931


Three-6 mg. of the drug/kg. of body wt. was given over a period of 7-10 days. The micro-filariae disappeared swiftly from the blood, requiring 7 days at the longest in a case of 19 yrs.' duration. However, the symptoms reappeared after about 3 weeks. In a 2d trial, the daily admn. of 0.4 g. of the drug for 10 days was followed by a period of 3-4 weeks before repetition (2-4 times) of the treatment. Symptoms were ameliorated quickly and were absent for a long time.