Serodiagnosis and immunological aspects of Proteus infection. III. Immunological, bacteriological and pathomorphological parallels in experimental Proteus intestinal infections, mono- and mixed


Bidnenko, S.I.; Bernasovskaia, E.P.; Barshteĭn, I.A.; Ganziĭ, G.P.

Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii 1982(10): 105-110

1982


The intraintestinal infection of 76 rabbits with P. mirabilis in a dose of 10(9) cells/kg, alone or in combination with Sh. sonnei, by the method modified by the authors caused a pathological process in the intestine, which was indicative of Proteus playing an independent role in the etiology of diarrheas. The process had its pronounced clinical, microbiological and immunological characteristics. Specific immunoglobulins, mainly H-antibodies, could be detected in different serological tests with the corresponding antigens, their pattern, level and avidity objectively reflecting the development of the infectious process. In mixed infections the pattern of the contamination of feces with the infective agents and their ability to form colonies after the inoculation of fecal samples were changed, while the level of antibodies to the associates was lower than in monoinfections.