The treatment of vitiligo with Ammi Majus Linn. A preliminary note
Sidi, E.; Bourgeois, G.Vardin, J.
Journal of Investigative Dermatology 18(5): 391-395
Ammi Majus Linn is a yearly umbelliferous plant closely related to the plant Ammi Visnaga, from which it can be differentiated only with difficulty with the naked eye. Ammi Majus Linn is well known in Egypt where it is found abundantly in the Nile delta, but it has also been grown in French soil. Since the 13th century the Egyptians have used a powder prepared from the fruit of this plant for the treatment of leukodermas. However, the powder of Ammi Majus Linn, just like that of Ammi Visnaga, provoked such undesirable manifestations as headache, nausea, vomiting, diarrhea, gastric burning and, when given in very strong doses, even nephritis and coma. In 1947, I. R. Fahmy and H. Abu-Shady (1) undertook to extract the active principle of this plant. They were able to isolate two crystalline bitter substances, close to the furocourmarines, namely Ammoidin (G 41180 4 with a melting point of 148°) and Ammidin (melting point 98°). They also assayed the toxic dose on toads and found it to be 400 mg per kg weight for Ammoidin and 800 mg per kg weight for Ammidin.