Solubility behavior of phenolic compounds in hexane-ethyl acetate, hexane-ethyl myristate, and hexane-ethyl pivalate cosolvent systems
Akaho, E.; Iga, K.; Kraal, J.; Hussain, A.
Journal of Pharmaceutical Sciences 70(11): 1225-1228
Interactions of phenolic compounds 4-hexylresorcinol and 3,4-dimethylphenol with esters were studied using hexane-ester cosolvent systems by both phase solubility and partitioning methods. The data obtained by the phase solubility method were variable and could not be analyzed by any mathematical model. The data obtained by the partitioning method, however, strongly suggest that 4-hexylresorcinol forms 1:1 and 1:2 complexes with the esters in hexane, while 3,4-dimethylphenol forms only 1:1 complexes with the same esters.