Lesions induced in the nasal turbinates of 25 to 35 day old piglets challenged with Pasteurella multocida and or Bordetella bronchiseptica

Mores, N.; Piffer, I.A.; Oliveira, A.

Arquivo Brasileiro de Medicina Veterinaria e Zootecnia 43(5): 411-422


Twenty-five to 35-day-old specific-pathogen-free (SPF) piglets were challenged with type A or D Pasteurella multocida and/or Bordetella bronchiseptica. Both strains of P. multocida, in a single rhinitis (AR) while the strain of B. bronchiseptica colonized the nasal cavity very well and induced moderate lesions of AR. Piglets challenged with both B. bronchiseptica and type D P. multocida showed consistent colonization by both species and severe AR, indicating a synergistic effect of both bacteria in inducing AR. In piglets inoculated with type D P. multocida alone, the only lesions observed were slight reduction of trabeculae and limited osteoblastic hyperplasia. Piglets infected with B. bronchiseptica or with both B. bronchiseptica and type D P. multocida had trabeculae that were reduced in size, scarcely present or replaced by mesenchymal cells and proliferating fibrous tissue due to osteogenesis reduction and marked osteoclastic osteolysis.