Gaschromatographic determination of the total furocoumarins and of the ratio of the furocoumarins xanthotoxin bergapten and isopimpinellin in their mixtures

Kabanov, V.S.; Gromakova, A.I.; Perel'son, M.E.

Khimiko-Farmatsevticheskii Zhurnal 17(7): 873-877


The principal Soviet photosensitizing preparations, ammifurin, beroxan and psoberan, contain the following furocoumarins: xanthotoxin; bergapten, isopimpinellin (III), and psoralen (IV). A method was developed for determining furocoumarins in natural mixtures and in model mixtures of I, II, III and IV using gas chromatography. The natural furocoumarin mixtures were isolated from Ammi majus fruits and Ficus carica leaves. The relative error of a single determination did not exceed 2% (for the total furocoumarins) and 3% (for the component composition).