Comparison of cell-mediated immune responses to Brucella abortus strain 19 vaccine and Brucella abortus killed 45/20 adjuvant vaccine in cattle


Chukwu, C.C.

Microbios Letters 34(134): 93-102

1987


Comparison of cell-mediated immune responses to Brucella abortus strain 19 vaccine and Brucella abortus K45/20 adjuvant vaccine in cattle indicated clearly that the adjuvant vaccine elicited higher responses than the attenuated strain 19 vaccine. The inability of strain 19 vaccine to stimulate adequate cell-mediated immune response might be due to lack of sensitized lymphocytes in the circulation or to insensitivity of the assays used (the lymphocyte transformation test and delayed hypersensitivity skin test) to detect the subsets of T lymphocytes stimulated by the vaccine. The degree of increased cell-mediated immune response in cattle immunized with K45/20A vaccine was probably due to stimulation of the reticuloendothelial system by the oil adjuvant.