Synergistic effect of Ir-(COT)-pentamidine alizarin red and pentamidine, amphotericin B, and paromomycin on Leishmania donovani
Mbongo, N.; Loiseau, P.M.; Craciunescu, D.G.; Robert Gero, M.
Acta Tropica 70(2): 239-245
The treatment of various human infections caused by parasitic organisms of the genus Leishmania is still based on pentavalent antimonials, an empirical treatment developed more than 50 years ago. Pentamidine is a molecule of high interest for curing early stages of African trypanosomiasis and both visceral and mucocutaneous leishmaniasis, refractory to pentavalent antimonials which is increasing in all areas of endemicity. The combination between a metallic structure and an organic moiety is one of the strategies in finding new antileishmanial drugs since it was demonstrated that organometallic compounds were less toxic and usually more active.