Copper toxicosis in Bedlington Terriers in the United Kingdom
Kelly, D.F.; Haywood, S.; Bennett, A.M.
Journal of Small Animal Practice 25(6): 293-298
This paper summarizes the clinical and laboratory data on two adult Bedlington Terriers with liver disease associated -with copper toxicosis. The younger dog, at 3 years, had elevated serum levels of alanine aminotransferase and alkaline phosphatase with active parenchymal cell degeneration and hepatitis. The second dog developed chronic hepatic failure at 5 years with advanced cirrhosis. Both dogs had stainable copper granules in the liver and chemical analysis of their livers revealed elevated copper contents (1,027 and 10,728,ug/g dry weight; normal less than 300,ug/g). These are the first published cases of this inherited abnormality of copper metabolism in this breed in this country.