Appetite stimulation and weight gain with cyproheptadine (periactin) in tuberculosis patients (double-blind clinical study)
Medical Journal of Malaysia 29(4): 270-274
It will be seen from the observations that the findings of our trial is in agreement with the above noted investigations that Cyproheptadine is a useful drug in stimulating appetite and weight gain. The patients receiving active drug showed mean weight gain of 10.55 lbs. whereas placebo group gained 4.25 obs. The differents of 6.30 lbs. in 16 weeks of Cyproheptadine therapy and follow-up is highly significant. The drug is particularly found useful for tuberculosis patients receiving PAS and Thiacetazone - the appetite depressant drug. Cyproheptadine is also recommended for patients suffering from other diseases having lack of appetite or poor weight gain. Above studies have established the efficacy of this drug but the specific mode of action is not known, further study is needed to reveal its mode of action.